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王伟毅，研究员，医学硕士，理学博士，入选福建省、厦门市高层次人才（C类）、所优秀青年科学家，从事海洋微生物活性物质研究。
先后主持国家级、省部级和横向项目近20项，包括国家自然科学基金面上项目、国家重点研发计划子课题、福建省自然科学基金面上项目、大洋专项子课题、教育部重点实验室基金等。
在Pharmacol. Res.、Anal. Chem.、J. Nat. Prod.、Bioorg. Chem.、Chinese Chem. Lett.和Appl. Microbiol. Biotechnol.等发表SCI论文近40篇，授权中国发明专利5项、软件著作权1项，获得2022年度海洋工程科学技术奖。兼任Front. Microbiol.客座编辑，J. Nat. Prod.长期审稿人，中国菌物学会专委会委员，宁波大学、福州大学、福建农林大学、沈阳药科大学（协同育人基地）客座导师，厦门市科技局、海洋发展局专家库成员。
研究方向
l 基于质谱和核磁共振的多组学、计算化学、计算机辅助药物设计等多学科的技术交叉融合，挖掘海洋新结构天然产物。
2 针对重大疾病的多种模型、靶点及信号通路，开展海洋新结构天然产物的药理学研究。
近期成果（2020-2024）：
1. Wang, W.#*; Yang, J. #; Liao, Y.-Y.; Cheng, G.; Chen, J.; Cheng, X.-D.*; Qin, J.-J.*; Shao, Z., Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7. Journal of Natural Products 2020, 83, 1157-1166.
2. Wang, W.#*; Yang, J.#; Liao, Y.-Y.; Cheng, G.; Chen, J.; Mo, S.; Yuan, L.; Cheng, X.-D.*; Qin, J.-J.*; Shao, Z., Aspeterreurone A, a Cytotoxic Dihydrobenzofuran-Phenyl Acrylate Hybrid from the Deep-Sea-Derived Fungus Aspergillus terreus CC-S06-18. Journal of Natural Products 2020, 83, 1998-2003.
3. Xia, J.#; Si, H.#; Huang, X.; Chen, X.; Fu, X.; Li, G.; Lai, Q.; Li, F.; Wang, W.*; Shao, Z.*, Metabolomics and Molecular Networking-Guided Screening of Bacillus-Derived Bioactive Compounds Against a Highly Lethal Vibrio Species. Analytical Chemistry, 2024, 96, 4359-4368.
4. Guan, X.#; Yang, J.#; Wang, W.#*; Zhao, B.; Hu, S.; Yu, D.; Yuan, L.; Shi, Y.; Xu, J.; Dong, J.; Wang, J.; Cheng, X.-D.*; Qin, J.-J.*, Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer. Pharmacological Research 2023, 189, 106703.
5. Yin, G.-P.; Gong, M.; Xue, G.-M.; Gong, T.; Cao, X.; Wang, W.*; Hu, C.-H.*, Penispidins A-C, Aromatic Sesquiterpenoids from Penicillium virgatum and Their Inhibitory Effects on Hepatic Lipid Accumulation. Journal of Natural Products 2021, 84, 2623-2629.
6. Wang, T.#; Tian, J.#; Huang, J.; Yuan, Y.; Naman, C. B.; Wu, S.; Wang, H.; Lin, W.; Tong, Z.; Ding, L.; Wang, W.*; He, S.*, Irpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088. Journal of Natural Products 2024, doi: 10.1021/acs.jnatprod.3c01078.
7. Yu, Z.-L.#; Zhou, M.-R. #; Wang, W.-Y. #; Chang, Y.-B.; Sun, C.-P.; Lv, X.; Wang, C.; Zhao, W.-Y.*; Ma, X.-C.*, Cytotoxic diterpenoid dimer containing an intricately caged core from Euphorbia fischeriana. Bioorganic Chemistry 2022, 123, 105759.
8. Peng, Y.; Chang, Y.; Sun, C.; Wang, W.; Wang, C.; Tian, Y.; Zhang, B.; Deng, S.; Zhao, W.*; Ma, X.-C.*, Octacyclic and decacyclic ent‑abietane dimers with cytotoxic activity from Euphorbia fischeriana steud. Chinese Chemical Letters 2022, 33, 4261-4263.
9. Zhao, W. Y.; Sun, C. P.; Chang, Y. B.; Wang, W.-Y.; Yan, J. K.; Lv, X.; Wang, C.*; Ma, X.-C.*, Unprecedented diterpenoid dimers with soluble epoxide hydrolase inhibitory effect from Euphorbia fischeriana. Organic & Biomolecular Chemistry 2022, 20, 2508-2517.
10. Hong, X.; Guan, X.; Lai, Q.; Yu, D.; Chen, Z.; Fu, X.; Zhang, B.; Chen, C.; Shao, Z.; Xia, J.*; Qin, J.-J.*; Wang, W.*, Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp. Applied Microbiology and Biotechnology 2022, 106, 2923-2935.
11. Lv, D.; Xia, J.; Guan, X.; Lai, Q.; Zhang, B.; Lin, J.; Shao, Z.; Luo, S.; Zhangsun, D.*; Qin, J.-J.*; Wang, W.*, Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426. Frontiers in Microbiology 2022, 13, 950857.
12. Pan, D.; Lin, S.; Huang, X.; Lv, D.; Lai, Q.; Xia, J.*; Shao, Z.; Wang, W.*, New polyketides and sesquiterpenoids from the deep-sea sulphide-derived fungus Phoma sp. 3A00413. Fitoterapia 2023, 168, 105546.
13. Yu, D.; Qi, S.; Guan, X.; Yu, W.; Yu, X.; Cai, M.; Li, Q.; Wang, W.*; Zhang, W.*; Qin, J.-J.*, Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer. Frontiers in Pharmacology 2022, 13, 870367.
14. Feng, S.*; Wang, W.*, Bioactivities and Structure-Activity Relationships of Natural Tetrahydroanthraquinone Compounds: A Review. Frontiers in Pharmacology 2020, 11, 799.
15. Zhang, J.#; Wang, W.#*; Zhou, Y.#; Yang, J.#; Xu, J.; Xu, Z.; Xu, B.; Yan, L.; Cheng, X.-D.; Li, M.*; Qin, J.-J.*, Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice. Frontiers in Pharmacology 2020, 11, 457.
16. Huang, X.#; Wang, Y.#; Li, G.; Shao, Z.; Xia, J.*; Qin, J. J.*; Wang, W.*, Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183. Frontiers in Microbiology 2024, 15, 1361550.
17. Wang, W.*; Wang, T. T.*, Editorial: Fungal secondary metabolites as valuable chemical entities for medicines and agrochemicals. Frontiers in Microbiology 2023, 14, 1150023.
王伟毅，研究员，医学硕士，理学博士，入选福建省、厦门市高层次人才（C类）、所优秀青年科学家，从事海洋微生物活性物质研究。
先后主持国家级、省部级和横向项目近20项，包括国家自然科学基金面上项目、国家重点研发计划子课题、福建省自然科学基金面上项目、大洋专项子课题、教育部重点实验室基金等。
在Pharmacol. Res.、Anal. Chem.、J. Nat. Prod.、Bioorg. Chem.、Chinese Chem. Lett.和Appl. Microbiol. Biotechnol.等发表SCI论文近40篇，授权中国发明专利5项、软件著作权1项，获得2022年度海洋工程科学技术奖。兼任Front. Microbiol.客座编辑，J. Nat. Prod.长期审稿人，中国菌物学会专委会委员，宁波大学、福州大学、福建农林大学、沈阳药科大学（协同育人基地）客座导师，厦门市科技局、海洋发展局专家库成员。
研究方向
l 基于质谱和核磁共振的多组学、计算化学、计算机辅助药物设计等多学科的技术交叉融合，挖掘海洋新结构天然产物。
2 针对重大疾病的多种模型、靶点及信号通路，开展海洋新结构天然产物的药理学研究。
近期成果（2020-2024）：
1. Wang, W.#*; Yang, J. #; Liao, Y.-Y.; Cheng, G.; Chen, J.; Cheng, X.-D.*; Qin, J.-J.*; Shao, Z., Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus Chaetomium globosum MP4-S01-7. Journal of Natural Products 2020, 83, 1157-1166.
2. Wang, W.#*; Yang, J.#; Liao, Y.-Y.; Cheng, G.; Chen, J.; Mo, S.; Yuan, L.; Cheng, X.-D.*; Qin, J.-J.*; Shao, Z., Aspeterreurone A, a Cytotoxic Dihydrobenzofuran-Phenyl Acrylate Hybrid from the Deep-Sea-Derived Fungus Aspergillus terreus CC-S06-18. Journal of Natural Products 2020, 83, 1998-2003.
3. Xia, J.#; Si, H.#; Huang, X.; Chen, X.; Fu, X.; Li, G.; Lai, Q.; Li, F.; Wang, W.*; Shao, Z.*, Metabolomics and Molecular Networking-Guided Screening of Bacillus-Derived Bioactive Compounds Against a Highly Lethal Vibrio Species. Analytical Chemistry, 2024, 96, 4359-4368.
4. Guan, X.#; Yang, J.#; Wang, W.#*; Zhao, B.; Hu, S.; Yu, D.; Yuan, L.; Shi, Y.; Xu, J.; Dong, J.; Wang, J.; Cheng, X.-D.*; Qin, J.-J.*, Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer. Pharmacological Research 2023, 189, 106703.
5. Yin, G.-P.; Gong, M.; Xue, G.-M.; Gong, T.; Cao, X.; Wang, W.*; Hu, C.-H.*, Penispidins A-C, Aromatic Sesquiterpenoids from Penicillium virgatum and Their Inhibitory Effects on Hepatic Lipid Accumulation. Journal of Natural Products 2021, 84, 2623-2629.
6. Wang, T.#; Tian, J.#; Huang, J.; Yuan, Y.; Naman, C. B.; Wu, S.; Wang, H.; Lin, W.; Tong, Z.; Ding, L.; Wang, W.*; He, S.*, Irpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088. Journal of Natural Products 2024, doi: 10.1021/acs.jnatprod.3c01078.
7. Yu, Z.-L.#; Zhou, M.-R. #; Wang, W.-Y. #; Chang, Y.-B.; Sun, C.-P.; Lv, X.; Wang, C.; Zhao, W.-Y.*; Ma, X.-C.*, Cytotoxic diterpenoid dimer containing an intricately caged core from Euphorbia fischeriana. Bioorganic Chemistry 2022, 123, 105759.
8. Peng, Y.; Chang, Y.; Sun, C.; Wang, W.; Wang, C.; Tian, Y.; Zhang, B.; Deng, S.; Zhao, W.*; Ma, X.-C.*, Octacyclic and decacyclic ent‑abietane dimers with cytotoxic activity from Euphorbia fischeriana steud. Chinese Chemical Letters 2022, 33, 4261-4263.
9. Zhao, W. Y.; Sun, C. P.; Chang, Y. B.; Wang, W.-Y.; Yan, J. K.; Lv, X.; Wang, C.*; Ma, X.-C.*, Unprecedented diterpenoid dimers with soluble epoxide hydrolase inhibitory effect from Euphorbia fischeriana. Organic & Biomolecular Chemistry 2022, 20, 2508-2517.
10. Hong, X.; Guan, X.; Lai, Q.; Yu, D.; Chen, Z.; Fu, X.; Zhang, B.; Chen, C.; Shao, Z.; Xia, J.*; Qin, J.-J.*; Wang, W.*, Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp. Applied Microbiology and Biotechnology 2022, 106, 2923-2935.
11. Lv, D.; Xia, J.; Guan, X.; Lai, Q.; Zhang, B.; Lin, J.; Shao, Z.; Luo, S.; Zhangsun, D.*; Qin, J.-J.*; Wang, W.*, Indole Diketopiperazine Alkaloids Isolated From the Marine-Derived Fungus Aspergillus chevalieri MCCC M23426. Frontiers in Microbiology 2022, 13, 950857.
12. Pan, D.; Lin, S.; Huang, X.; Lv, D.; Lai, Q.; Xia, J.*; Shao, Z.; Wang, W.*, New polyketides and sesquiterpenoids from the deep-sea sulphide-derived fungus Phoma sp. 3A00413. Fitoterapia 2023, 168, 105546.
13. Yu, D.; Qi, S.; Guan, X.; Yu, W.; Yu, X.; Cai, M.; Li, Q.; Wang, W.*; Zhang, W.*; Qin, J.-J.*, Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer. Frontiers in Pharmacology 2022, 13, 870367.
14. Feng, S.*; Wang, W.*, Bioactivities and Structure-Activity Relationships of Natural Tetrahydroanthraquinone Compounds: A Review. Frontiers in Pharmacology 2020, 11, 799.
15. Zhang, J.#; Wang, W.#*; Zhou, Y.#; Yang, J.#; Xu, J.; Xu, Z.; Xu, B.; Yan, L.; Cheng, X.-D.; Li, M.*; Qin, J.-J.*, Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice. Frontiers in Pharmacology 2020, 11, 457.
16. Huang, X.#; Wang, Y.#; Li, G.; Shao, Z.; Xia, J.*; Qin, J. J.*; Wang, W.*, Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183. Frontiers in Microbiology 2024, 15, 1361550.
17. Wang, W.*; Wang, T. T.*, Editorial: Fungal secondary metabolites as valuable chemical entities for medicines and agrochemicals. Frontiers in Microbiology 2023, 14, 1150023.
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