何建林，博士，副研究员，硕士生导师。四川大学华西药学本科，硕士。2008年进入海洋三所工作。2015年前往美国西东大学神经免疫药理研究所访问1年。2017年获南京中医药大学中药药理学博士学位。

从事海洋天然产物干预代谢相关疾病研究。主持科研项目15项；发表研究论文40篇，通讯/第一作者发表SCI论文14篇；获得国家发明专利授权8项。主要创新性成果包括以下三个方面：

（1）发现海洋天然产物DHA缓解神经炎症以及保护肝损伤的新活性，并与相关企业合作开发了高纯DHA的制备方法；

（2）基于肝星状细胞活化机制揭示天然产物抗肝纤维化作用的分子机理；

（3）筛选海洋微生物代谢产物的活性，促进海洋药物开发。

发表研究论文列表（2017-至今）：

1. He J, Le Q, Wei Y, et al. Effect of piperine on the mitigation of obesity associated with gut microbiota alteration[J]. Current Research in Food Science, 2022, 5: 1422-1432.

2. He J, Wu X, Huang S, et al. Phenolic Metabolites from a Deep-Sea-Derived Fungus Aspergillus puniceus A2 and Their Nrf2-Dependent Anti-Inflammatory Effects[J]. Marine Drugs, 2022, 20(9): 575.

3. Zhang Y, Zhao N, Yang L, Hong Z, Cai B, Le Q, Yang T, Shi L, He J*, Cui CB. Insoluble dietary fiber derived from brown seaweed Laminaria japonica ameliorate obesity-related features via modulating gut microbiota dysbiosis in high-fat diet–fed mice[J]. Food & Function, 2021, 12(2): 587-601.

4. Zhang Y, Zhao N, Yang L, Hong Z, Cai B, Le Q, Yang T, Shi L, He J*. Soluble polysaccharide derived from Laminaria japonica attenuates obesity-related nonalcoholic fatty liver disease associated with gut microbiota regulation[J]. Marine drugs, 2021, 19(12): 699.

5. He J, Hong B, Lu R, et al. Separation of saturated fatty acids from docosahexaenoic acid‐rich algal oil by enzymatic ethanolysis in tandem with molecular distillation[J]. Food Science & Nutrition, 2020, 8(5): 2234-2241.

6. He J, Hong B, Bian M, et al. Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner[J]. International Immunopharmacology, 2019, 75: 105816.

7. He J, Huang W, Zheng S, et al. Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats[J]. Journal of neurovirology, 2018, 24(1): 88-97.

8. He J, Bai K, Hong B, et al. Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats[J]. International Immunopharmacology, 2017, 53: 56-62.

9. Hong B, He J, Le Q, et al. Combination formulation of tetrodotoxin and lidocaine as a potential therapy for severe arrhythmias[J]. Marine drugs, 2019, 17(12): 685.

10. Bian M, He J, Jin H, et al. Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress[J]. Apoptosis, 2019, 24(11): 905-920.

11. Hong B, He J, Sun J, et al. Analgesia Effect of Enteric Sustained-Release Tetrodotoxin Pellets in the Rat[J]. Pharmaceutics, 2020, 12(1): 32.

12. Hong B, He J, Fan C, et al. Synthesis and Biological Evaluation of Analogues of Butyrolactone I as PTP1B Inhibitors[J]. Marine drugs, 2020, 18(11): 526.

13. Niu S, He J, Huang S, et al. Phaeosphamides A and B, Cytotoxic Cyclodecadepsipeptides from the Mangrove-Derived Fungus Phaeosphaeriopsis sp. S296[J]. Marine Drugs, 2022, 20(10): 591.

14. Gao X, He J, Chen J, et al. Double-spotted pufferfish (Takifugu bimaculatus) skin collagen: Preparation, structure, cytocompatibility, rheological, and functional properties[J]. Arabian Journal of Chemistry, 2023, 16(1): 104402.